Breast Cancer

Population-scale integration of tumor transcriptomics into breast cancer care: a decade of the SCAN-B initiative
Background
Population-scale molecular profiling integrated into routine healthcare could accelerate biomarker discovery, validation, …
Lao H. Saal, Hina Dalal, Pei Meng, Christian Brueffer, Sergii Gladchuk, Sofia K. Gruvberger-Saal, Jari Häkkinen, Nicklas Nordborg, Minerva Li, Jeanette Valcich, Ingrid Hedenfalk, Anders Edsjö, Fredrika Killander, Emma Niméus, Pär-Ola Bendahl, Carina Forsare, Jonas Manjer, Janne Malina, Martin Rehn, Kristina Åhsberg, Christian Ingvar, Fredrik Graffner, Lars Åhlund, Bengt Asking, Maria Erngrund, Monika Sjövall, Asa Cetti, Tor Svensjö, Heitti Teder, Johanna Björkman, Lena Myrskog, Anna-Karin Falck, Ann-Christine Källström, Zakaria Einbeigi, Patrícia Ribeiro Bragança, Henrik Lindman, Tobias Sjöblom, Martin Malmberg, Christer Larsson, Anna Ehinger, Lisa Rydén, Niklas Loman, Cecilia Hegardt, Åke Borg, Johan Vallon-Christersson
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Transcriptomic Profiling of Mouse Mammary Tumors Enables Prognostic and Predictive Biomarker Discovery for Human Breast Cancer
The development and validation of prognostic and predictive biomarkers in breast cancer is limited by the availability of …
Matthew D. Sutcliffe, Kevin R. Mott, Tulay Yilmaz-Swenson, Brooke M. Felsheim, Alexander V. Lobanov, Anna R. Michmerhuizen, Patrick D. Rädler, Denis O. Okumu, Xiaping He, Adam D. Pfefferle, Stephanie Dance-Barnes, Christian Brueffer, Lao H. Saal, Michael P. East, Daniel P. Hollern, Timothy C. Elston, Gary L. Johnson, Charles M. Perou
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NeoCircle: pre- and post-operative circulating tumor DNA dynamics predicts survival in neoadjuvant-treated early breast cancer
Persistent circulating tumor DNA (ctDNA) during neoadjuvant treatment (NAT) of early breast cancer (EBC) indicates high-risk disease. …
Anthony M. George, Yilun Chen, Sergii Gladchuk, Miguel Alcaide, Hina Dalal, Pei Meng, Christian Brueffer, Hani Saghir, Siker Kimbung, Kristina Aaltonen, Lucia Oton, Christopher Rushton, Sofia Birkeälv, Mats Jönsson, Sophia Zackrisson, Ida Skarping, Daniel Förnvik, Lina Zander, Gabriella Honeth, Samuel Woodhouse, Karen Howarth, Åke Borg, Anna Ehinger, Martin Malmberg, Lisa Rydén, Niklas Loman, Lao H. Saal
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Abstract PS1-05: Genomic characteristics related to histology-based immune features in breast cancer
Background: The immune cell component of the tumor microenvironment is an important modulator of tumor progression and suppression. In …
Yoon Jin Cha, Constandina E. O’Connell, Benjamin C. Calhoun, Christian Brueffer, Christer Larsson, Åke Borg, Lao H. Saal, Charles M. Perou
DOI
Abstract PS1-05: Genomic characteristics related to histology-based immune features in breast cancer
NeoCircle: Investigating circulating tumor DNA dynamics as a predictor of survival in primary breast cancer
Background
Persistent circulating tumor DNA (ctDNA) detection during neoadjuvant treatment (NAT) of early-breast cancer (EBC) indicates …
Anthony M. George, Yilun Chen, Sergii Gladchuk, Miguel Alcaide, Hina Dalal, Pei Meng, Christian Brueffer, Hani Saghir, Siker Kimbung, Lucia Oton, Ida Skarping, Daniel Förnvik, Gabriella Honeth, Karen Howarth, Åke Borg, Anna Ehinger, Martin Malmberg, Lisa Rydén, Niklas Loman, Lao H. Saal
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NeoCircle: Investigating circulating tumor DNA dynamics as a predictor of survival in primary breast cancer
Genomic Characteristics Related to Histology-based Immune Features in Breast Cancer
The immune cell component of the tumor microenvironment is an important modulator of tumor progression. In patients with breast cancer, …
Yoon Jin Cha, Constandina E. O’Connell, Benjamin C. Calhoun, Brooke M. Felsheim, Aranzazu Fernandez-Martinez, Cheng Fan, Christian Brueffer, Christer Larsson, Åke Borg, Lao H. Saal, Charles M. Perou
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Monitoring ctDNA dynamics in early breast cancer using a novel ultra-sensitive tumor-informed structural variant approach combining whole-genome sequencing and multiplex dPCR
Background
Persistent circulating cell-free tumor DNA (ctDNA) detection during neoadjuvant treatment of early-breast cancer (EBC) …
Lao H. Saal, Niklas Loman, Yilun Chen, Miguel Alcaide, Christian Brueffer, Sergii Gladchuk, Hina Dalal, Pei Meng, Anthony M. George, Sofia Birkeälv, Hani Saghir, Siker Kimbung, Daniel Förnvik, Lina Zander, Gabriella Honeth, Karen Howarth, Åke Borg, Anna Ehinger, Martin Malmberg, Lisa Rydén
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Monitoring ctDNA dynamics in early breast cancer using a novel ultra-sensitive tumor-informed structural variant approach combining whole-genome sequencing and multiplex dPCR
Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a …
Tommaso De Marchi, Chun-Fui Lai, Georgia M. Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H. Saal, Johan Malmström, Simak Ali, Emma Niméus
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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
Digital PCR quantification of ultrahigh ERBB2 copy number identifies poor breast cancer survival after trastuzumab
HER2/ERBB2 evaluation is necessary for treatment decision-making in breast cancer (BC), however current methods have limitations and …
Pei Meng, Hina Dalal, Yilun Chen, Christian Brueffer, Sergii Gladchuk, Miguel Alcaide, Anna Ehinger, Lao H. Saal
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Digital PCR quantification of ultrahigh ERBB2 copy number identifies poor breast cancer survival after trastuzumab
Clinical associations of ESR2 (estrogen receptor beta; ERβ) expression across thousands of primary breast tumors
Estrogen receptor alpha (ERα, encoded by ESR1) is a well-characterized transcription factor expressed in more than 75% of breast tumors …
Hina Dalal, Malin Dahlgren, Sergii Gladchuk, Christian Brueffer, Sofia K. Gruvberger-Saal, Lao H. Saal
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Clinical associations of ESR2 (estrogen receptor beta; ERβ) expression across thousands of primary breast tumors