Proteomics

ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner
ESR1 mutations are a driver of endocrine therapy resistance in breast cancer, however their impact on protein signaling pathways and …
Tommaso De Marchi, Magdalena Kuras, Lazaro H. Betancourt, Sven Kjellström, Jeanette Valchich, Johan Vallon-Christersson, Christian Brueffer, Lao H. Saal, Johan Malmström, Emma Niméus
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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a …
Tommaso De Marchi, Chun-Fui Lai, Georgia M. Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H. Saal, Johan Malmström, Simak Ali, Emma Niméus
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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling